Notes from the work
Longer pieces on leadership, change and taking research to market in regulated and service businesses. Each one is a PDF, free to download. There is nothing to sign up for.
The Valley of Death
For every hundred inventions US universities record, fewer than three new products reach the market, and the 2025–2026 federal funding shock has turned that chronic gap into an acute one. This paper argues the Valley of Death is a structural failure, not only a funding one, and looks at what the global bridge-builders do differently. It makes the case that the biggest opening is for operators who bring tooling and training rather than capital alone, with reformulation of poorly soluble molecules as an undervalued front.
Download PDF ↓Managing Stability in an Age of Constant Change
AI has made change constant, and the classic change models assume a stable "after" that no longer arrives. This paper argues that stability is now the scarce resource leaders must manage on purpose, drawing on pharmaceutical change control, hospitality and professional services. It offers a four-question framework (Anchors, Capacity, Timing and Value) and a one-page stability check to use before the next change.
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Graticus is part of AGCP Farmacêuticos. Lawrence Fine on LinkedIn